Step 1 Prep Course Review

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Step 1 Course Review Created by Yale Students Who Scored Perfect. Includes Online Course, Qbank, Flashcards, EKG
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Complete Step 1 Online Course Review Includes

Course Review
Our Step 1 course offers thorough preparation with multi-step reasoning questions and detailed explanations, ensuring a deep understanding of core concepts.
Step 1 Qbank
The UMock Qbank offers multi-step reasoning questions and detailed explanations with the latest evidence-based content for Step 1 preparation. Use our proven study methods to boost your exam performance.
Pre-made Flashcards
Premade flashcards with clear, concise content for efficient memorization. Perfect for quick and easy review.
EKG Review
Study EKG interpretations with images, animations, and tracings to master arrhythmias, myocardial infarctions, and EKG principles for Step 1 preparation.

Step 1 Course Review Features

The Step 1 course review is designed to provide comprehensive and effective preparation. It includes integrated, multi-step reasoning questions alongside in-depth explanations, ensuring that you understand the core concepts at a deeper level. Our content is grounded in the latest evidence-based clinical knowledge, offering you the most current material for the Step 1 exam.

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Step 1 Online Course Review

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Prepare for the Step 1 exam with a review that covers 153 essential chapters, featuring multi-step reasoning questions and in-depth explanations.

Built on the latest evidence-based clinical knowledge, the course offers concise reviews, key facts, and detailed visuals to enhance understanding.

This integrated approach ensures you apply clinical concepts effectively to patient scenarios, setting you up for success.

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Step 1 Course for Success

The Step 1 review program offers a dynamic approach to mastering essential medical concepts.

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The course is continuously updated with the latest clinical guidelines and exam trends, ensuring you're equipped with the most current, evidence-based knowledge.

Includes Step 1 Pre-made Flashcards with 401+

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Flashcard 1 of 150

A 35-year-old man

  • Has a 10-year history of mild hypertension that is controlled through diet.
  • The patient presents to the office for a review of lab work and the physician explains that he has a new finding of elevated levels of cortisol and that additional testing is required to identify the source.
  • The physician explains that one of the functions of cortisol is to increase blood pressure and states concern that the patient’s blood pressure may not be appropriately controlled with the elevated levels of cortisol.
At what point in the day are cortisol levels and the patients’ blood pressure the highest?

Explanation

Cortisol is released in the body in a circadian rhythm and the highest levels of cortisol are measured in the morning typically immediately after waking up. Cortisol is stimulated by many factors including stress and pain and can be elevated due to a number of physical and environmental factors.

Cortisol Source:

Adrenal cortex (zona fasciculata)

Functions:

Metabolism

  • Stimulates gluconeogenesis
  • Stimulates glycogen synthesis
  • Stimulate lipolysis and proteolysis
  • Increases appetite
  • Increases insulin resistance

Impairs inflammatory and immune responses

  • Inhibits IL-2 production
  • Inhibits neutrophil adhesion (neutrophilic leukocytosis)
  • Increases sequestration and apoptosis of eosinophils and lymphocytes
  • Decreases production of leukotrienes and prostaglandins via inhibition of phospholipase A2
  • Inhibits release of histamine from mast cells
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Flashcard 2 of 150

A 12-year-old female

  • presents to the hospital with severe malaise and a fever.
  • Labs show that the patient is hyponatremic and hyperkalemic and there is an elevated ACTH.
  • Physical exam findings include non-blanching pinpoint macules on her legs and trunk.
  • The patient is diagnosed with Waterhouse-Friedrichsen syndrome and is immediately treated with IV hydrocortisone.
What organism is the most likely cause of this patient’s adrenal hemorrhage?

Answer

Diagnosis: Waterhouse-Friedrichsen syndrome

Treatment: Treat underlying cause, IV fluids and hydrocortisone

Waterhouse-Friedrichsen syndrome is most often a complication of Neisseria Meningitis in children and asplenic patients. It causes bilateral adrenal gland hemorrhage which leads to acute adrenal insufficiency. Other causes of Waterhouse-Friedrichsen syndrome are less common but include low platelet count, antiphospholipid syndrome, renal vein thrombosis, and corticosteroid use.

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Flashcard 3 of 150

img Identify radiological image

Answer

Pneumocystis Pneumonia.

Note atypical features on chest X-ray, which shows finely granular/miliary appearance.

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Flashcard 4 of 150

img Identify radiological image

Answer

Mediastinal Shift

Note the shift to the right in case of subtotal atelectasis of the right lung in case of bronchial carcinoma (arrow). The arrowheads point to the trachea, which has been shifted to the right.

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Flashcard 5 of 150

A 73-year-old female

  • presents to the physician with a painless goiter that has existed for approximately 9 years and multiple palpable nodules.
  • The patient recently began to experience arrhythmias, tachycardia, anxiety, muscle weakness, hyperreflexia, and irritability.
  • A radioiodine scan shows patchy uptake, and a biopsy is performed with the results shown below.

What is the most likely diagnosis?

Answer

Diagnosis: Toxic Multinodular Goiter

Treatment: Treat symptoms of hyperthyroidism, thyroidectomy

The patient most likely has a toxic multinodular goiter. The painless goiter with enlarged nodules in an elderly woman with symptoms of hyperthyroidism raises the suspicion for toxic multinodular goiter. The histology shows distended follicular cells with increased colloid and decreased epithelium. These findings are strongly indicative of toxic multinodular goiter.

Pathophysiology:

  • Hyperactive areas of thyroid produce excess T4 and T3 → ↓TSH → atrophy of other areas of thyroid

Epidemiology:

  • More common in elderly women. Rarely malignant.

Diagnosis:

  • Patchy uptake on radioiodine scan
  • Multiple nodules contained within the thyroid parenchyma

Histological Findings:

  • Patches of distended follicular cells with increased colloid and decreased epithelium
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Flashcard 6 of 150

A 8-year-old female

  • presents with a webbed neck, a broad chest, and a short stature.
  • She has previously been diagnosed with cortication of the aorta and horseshoe kidney.
  • Over the next few weeks, the patient begins to urinate much more frequently and although she is drinking a very large volume of fluids, she still feels thirsty.
  • The patient has also felt fatigued, and her mother believes her appetite has increased significantly.

What adverse effect of the patient’s pharmacotherapy is causing these new symptoms?

Answer

The patient has Turner syndrome and was prescribed human growth hormone to increase her height. Human growth hormone has the adverse effect of increasing insulin resistance. The symptoms of polyuria, polydipsia, and polyphagia are indicative of hyperglycemia secondary to insulin resistance.

Human Growth Hormone Mechanism

  • GH analog

Adverse Effects

  • Insulin resistance

Clinical Applications

  • GH deficiency
  • Turner syndrome
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Flashcard 7 of 150

A 39-year-old man

  • has a suspected thyroid cancer, and a biopsy is sent to pathology.
  • The pathology report states that there are large, empty-appearing nuclei with central clearing, nuclear groves, and psammoma bodies.

What is the most likely diagnosis?

Answer

The histological features and image are indicative of papillary carcinoma. It is the most common type of thyroid cancer and is marked by psammoma bodies and “orphan Annie” nuclei.

Epidemiology:

  • Most common type of thyroid cancer (75-80% of cases).
  • Peak incidence is seen in patients between 30 and 50 years of age
  • Well-differentiated cells and therefore associated with a very good prognosis.
  • Associated with RET/PTC rearrangements, BRAF mutations, and exposure to ionizing radiation, especially during childhood (i.e. as radiation therapy for another type of cancer such as lymphoma).

Clinical Features:

  • May be asymptomatic
  • Local effects may result in hoarseness, dysphagia, dyspnea, or rarely, Horner syndrome or venous obstruction (e.g. SVC syndrome)

Histological Findings:

  • Large, empty-appearing nuclei with central clearing (“Orphan Annie” nuclei),
  • Psammoma bodies (concentric calcifications),
  • Nuclear grooves
  • Thyroglobulin tumor marker
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High-Yield Flashcards by Subjects and Topics:

These premade flashcards are filled with engaging and effective blueprint concepts, including high-quality images, charts, tables, diagrams, and illustrations, all created by Yale's perfect 528 scorers.

Rapid Retention:

Designed with concise and focused facts, the premade flashcards enable quick learning and easy retention, making them an indispensable tool in your MCAT preparation.

The team behind UMock Step 1 with Perfect scores

Perfect scores

anushka

Anushka

Yale University

anjali

Anjali

Yale University

anjali

Mike

Orthopedic Surgery

Casey

Casey

Neurologist

julia

Julia

Internal medicine (MD)

Each subject review was written by students from Yale University with perfect exam scores. Each subject is condensed into an exceptionally easy-to-learn format with engaging content to more effectively retain concepts.

Anushka

Perfect Score

She graduated magna cum laude from Yale University with a B.S. in Molecular, Cellular, and Developmental Biology. She is currently a fourth-year medical student. She received perfect scores on the MCAT (528/528) and SAT (1600/1600), and has extensive experience for the MCAT, SAT, and AP exams. At Yale, she conducted genetics research and was the recipient of multiple research fellowships. During high school, she was a two-time finalist (top 20) in the U.S. National Chemistry Olympiad and was one of 80 students worlwide selected to attend the prestigious Research Science Institute (RSI) at MIT.

Scores:

  • MCAT: 528 / 528
  • SAT: 1600 / 1600
  • AP Biology: 5 / 5
  • AP Chemistry: 5 / 5
  • AP Physics C: 5 / 5
  • AP Calculus: 5 / 5
  • AP English Language and Composition: 5 / 5
  • AP English Literature and Composition: 5 / 5

Anjali

Perfect Score

She graduated magna cum laude from Yale University with a B.S. in Molecular, Cell, and Development in Biology and distinction in her major. Anjali Walia is a fourth-year medical student. She was also elected to the prestigious Phi Beta Kappa honor society. She achieved a perfect score (528/528) on the MCAT. At Yale, she published pulmonary research and led numerous reproductive justice advocacy efforts. She was finalist (Top 20) of the U.S. Chemistry Olympiad and obtained a perfect score on the SAT (1600/1600).

Scores:

  • MCAT: 528/528
  • SAT: 1600/1600
  • AP Biology: 5
  • AP Chemistry: 5
  • AP Physics I: 5
  • AP Physics C: 5
  • AP Computer Science: 5
  • AP Calculus: 5
  • AP English Language and Composition: 5
  • AP English Literature and Composition: 5

Mike

Perfect Score

  • Education:
  • Georgetown University, B.S.
  • Medical school/Residency:
  • Rutgers Robert Wood Johnson Medical School, M.D.
    Orthopedics Surgery
  • MCAT: 528 / 528
  • USMLE Score:
  • Step 1 - Pass
  • Step 2CK - 245
  • Step 3 - 252
  • SAT Subject Test –
  • Biology (Molecular): 780 / 800
  • Mathematics Level 2: 780 / 800
  • Mathematics Level 1: 750 / 800
  • SAT with Essay: 2330 / 2400
  • Reading: 800 / 800
  • Writing: 770 / 800
  • Math: 760 / 800
  • Chem/Phys: 131 / 136
  • CARS: 131 / 136
  • Bio/Biochem: 130 / 136
  • Psych/Soc: 130 / 136
  • AP Biology: 5 / 5
  • AP Statistics: 5 / 5
  • AP Calculus: 5 / 5

Casey

Perfect Score

Casey Vickstrom graduated summa cum laude from Northwestern University in 2014 with a B.A. in Biological Sciences. He is a third-year medical student in the MD/PhD program at the Medical College of Wisconsin, having completed his PhD in Neuroscience in 2020. His research focused on neural circuits and endocannabinoids related to anxiety and depression. He aims to study mechanisms of neurological diseases to identify new therapeutic targets. Casey has extensive tutoring experience for Step 1 and plans to pursue a career in neurology or related specialties. In his free time, he enjoys skiing, soccer, and spending time with family, friends, and his dog.

  • Education:
  • Northwestern University B.A.Honors
  • Medical College of Wisconsin
  • Medical Scientist Training Program (MD/PhD) at present
  • Score:
  • Step 1 - 265/300
  • ACT - 35/36
  • AP Biology - 5/6
  • MCAT - 515/528
  • Biology / Organic chem - 131/136
  • Physical Sciences - 127/136
  • Reading - 127/136

Julia

Perfect Score

Julia is a resident in Internal Medicine. She first developed an interest in helping other students succeed as a high school student, after scoring a 2310 on her own SATs. She went on to earn a Bachelor of Science in Health Care Management and Policy from Georgetown University, Washington, D.C with a concentration in healthcare administration. After earning a 520 and scoring in the 98th percentile on her MCAT exam, Julia continued straight from Georgetown to Sidney Kimmel Medical College at Thomas Jefferson University, in Philadelphia, PA.

  • Score:
  • USMLE® Step 1 - Pass
  • USMLE® Step 2CK - 262/300
  • USMLE® Step 3 - 263/300

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UMock Step 1 Content

Biochemistry Cardiology Endocrinology Gastrointestinal General pathalogy Genetics Hematology and Oncology Immunology Integumentary
Microbiology Musculoskeletal Neurology Pharmacology Psychiatry Public health The Pulmonary System Renal Reproduction
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Biochemistry course review topics in UMock

 
  • Nucleic acids
  • Purine synthesis
  • Antimetabolites
  • DNA structure
  • DNA and RNA comparison
  • Chromatin structure
  • Chromatin regulation
  • Central dogma
  • DNA replication
  • DNA damage
  • DNA repair
  • LAC operon
  • RNA
  • Spliceosome
  • RNA translation
  • Amino acids
  • Protein structure
  • Cell membrane
  • Cell membrane proteins
  • Cellular transport
  • Exocytosis and endocytosis
  • Endocytosis
  • Ubiquitin
  • Cellular respiration
  • Carbohydrates
  • Glycolysis
  • Pyruvate
  • Glycogen
  • Glycogen breakdown
  • Glycogen storage diseases
  • Kreb’s cycle
  • Amino acid catabolism
  • Fatty acid oxidation
  • Fatty acid metabolism
  • Mitochondrial shuttles
  • Mitochondria
  • Mitochondrial genome
  • Electron transport chain
  • Cell respiration
  • Urea cycle
  • Inborn errors of urea cycle
  • Cori cycle
  • Amino acid metabolism
  • Phenylketonuria
  • Tyrosine catabolism
  • Catecholamine synthesis
  • Cystinuria
  • Alkaptonuria
  • Vitamin B1
  • Vitamin B2
  • Vitamin B3
  • Vitamin B4
  • Vitamin B5
  • Vitamin B6
  • Vitamin B7
  • Vitamin B12
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin K
  • Magnesium
  • Copper metabolism
  • Micronutrients

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Cardiology course review topics in UMock

 
  • Introduction to cardiovascular system
  • Cardiac anatomy
  • Cardiac physiology
  • Cardiovascular pathophysiology
  • Cardiovascular pharmacology

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Endocrinology course review topics in UMock Content Review

 
  • Introduction to endocrinology
  • The thyroid gland
  • The hypothalamus and pituitary
  • The adrenal glands
  • The parathyroid glands
  • The endocrine pancreas

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Gastrointestinal course review topics in UMock Content Review

 
  • Introduction to the gastrointestinal system
  • Gastrointestinal anatomy
  • Gastrointestinal physiology
  • Gastrointestinal pathophysiology
  • Gastrointestinal pharmacology

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General pathalogy course review topics in UMock Content Review

 
  • Tumor
  • Tumorigenesis
  • Cancer associations
  • Cancer genes
  • Carcinogens
  • Carcinogens
  • Tumor grade and stage
  • Tissue and serum markers
  • Oncogenic pathogens
  • Cancer manifestations
  • Histological markers
  • Paraneoplastic syndromes
  • Common tumors
  • Cancer risk factors

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Genetics course review topics in UMock Content Review

 
  • Cell division
  • Terminology
  • Cytogenetics
  • Population genetics
  • Mutation detection
  • Genetic disorders by chromosome
  • Prenatal counseling & diagnostics
  • Chromosome deletion
  • Nondisjunction
  • Down syndrome
  • Trisomies
  • Sex chromosomes
  • Mutation subtypes
  • Genetic inheritance
  • Enzyme deficiency disorders
  • Cystic fibrosis
  • Genetic inheritance
  • Muscular dystrophies
  • Mitochondrial inheritance
  • Multifactorial inheritance
  • Triplet repeat disorders
  • Imprinting
  • Chromosome abnormalities
  • Molecular biology techniques
  • Genetic mapping and linkage
  • Gene cloning
  • Reverse genetics

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Hematology and Oncology course review topics in UMock Content Review

 
  • Embryology
  • Anatomy
  • Physiology
  • Anatomy
  • Brachial plexus
  • Pathology
  • Birth related injuries
  • Childhood disorders
  • Anatomy
  • Collagen disorders
  • Common fractures
  • Shoulder dislocation
  • Fracture repair
  • Neck anatomy
  • Neck triangles
  • Blood supply
  • Shoulder anatomy
  • Upper arm anatomy
  • Forearm anatomy
  • Hand anatomy
  • Carpal tunnel syndrome
  • Wrist pathology
  • Hand deformities
  • Knee anatomy
  • Knee pathology
  • Hip joint
  • Vascular supply
  • Hip and thigh anatomy
  • Lower leg anatomy
  • Venous system
  • Venous system
  • Lower limp
  • Thigh anatomy
  • Femoral triangle
  • Foot anatomy
  • Back pain
  • Disk herniation
  • Refereed pain
  • Vertebral disorders

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Immunology course review topics in UMock Content Review

 
  • Cellular injury
  • Lymphoid structures
  • Cellular components
  • Cellular pathways
  • Humoral mediators
  • Inflammatory response
  • Immune cells
  • Immune response
  • Humoral immunity
  • Immune dysfunction

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Integumentary course review topics in UMock Content Review

 
  • Skin anatomy
  • Dermatological terminology
  • Common skin disorders
  • Skin tumors
  • Skin ulcers
  • Drug-induced cutaneous reactions
  • Cutaneous infections
  • Cutaneous burn injuries

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Microbiology course review topics in UMock Content Review

 
  • Staining techniques
  • Microscopy techniques
  • Bacteria
  • Bacterial structure
  • Culture techniques
  • Toxins
  • Bacterial characteristics
  • Staphylococcus
  • Streptococcus
  • Bacillus
  • Listeria
  • Clostridium
  • Rickettsial disease
  • Ehrlichiosis

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Musculoskeletal course review topics in UMock Content Review

 
  • Embryology
  • Anatomy
  • Physiology
  • Anatomy
  • Brachial plexus
  • Pathology
  • Birth related injuries
  • Childhood disorders
  • Anatomy
  • Collagen disorders
  • Common fractures
  • Shoulder dislocation
  • Fracture repair
  • Neck anatomy
  • Neck triangles
  • Blood supply
  • Shoulder anatomy
  • Upper arm anatomy
  • Forearm anatomy
  • Hand anatomy
  • Carpal tunnel syndrome
  • Wrist pathology
  • Hand deformities
  • Knee anatomy
  • Knee pathology
  • Hip joint
  • Vascular supply
  • Hip and thigh anatomy
  • Lower leg anatomy
  • Venous system
  • Lower limp
  • Thigh anatomy
  • Foot anatomy
  • Back pain
  • Disk herniation
  • Refereed pain
  • Vertebral disorders
  • Compartment syndrome
  • Common pathologies
  • Bone pathology
  • Benign bone tumors
  • Malignant bone tumors
  • Overview
  • Elastic fiber disorders
  • Ehlers-danlos disorder
  • Rheumatoid arthritis
  • Osteoarthritis
  • Psoriatic arthritis
  • Gout
  • Pseudogout
  • Gout and pseudogout
  • Ana patterns
  • Lupus
  • Neonatal lupus
  • Lupus nephritis
  • Antiphospholipid syndrome
  • Scleroderma
  • Giant cell arteritis
  • Sjögren syndrome
  • Erythema nodosum
  • Vasculitis
  • Fibromyalgia
  • Pharmacology
  • Femoral triangle

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Neurology course review topics in UMock Content Review

 
  • Embryology
  • Neurophysiology
  • Neuroanatomy
  • Neuropathology
  • Guide to brainstem lesions
  • Brainstem vascular syndromes
  • Brainstem vascular syndromes
  • Cranial nerves
  • Cranial nerves
  • Autonomic nervous system
  • Sympathetic innervation
  • Parasympathetic innervation
  • Reflexes
  • Primitive reflexes
  • Sympathetic innervation
  • Spinal lesions
  • Spinal tracts
  • Spinal cord syndromes
  • Cns tumors
  • Sleep physiology
  • Headaches
  • Seizure disorders
  • Seizures
  • Olfactory nerve
  • Gustatory system
  • Vestibular system
  • Ophthalmology
  • Pupil reflex
  • Eye-blink reflex
  • Ophthalmology
  • Cns pharmacology
  • Cranial nerve nuclei

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Pharmacology course review topics in UMock Content Review

 
  • Reaction kinetics
  • Pharmacokinetics
  • Cytochrome p450
  • The adrenal glands
  • Acid-base chemistry
  • Efficacy and potency
  • Enzyme inhibitors
  • Allosteric modulators
  • Receptor agonist
  • G-protein family
  • G-protein -coupled receptors
  • Second messenger systems
  • Ligand-gated ion channels
  • Ion channels
  • Sympathetic system
  • Sympathomimetics
  • Sympatholytics
  • Adrenergic agents
  • Adrenergic response
  • Parasympathetic system
  • Parasympathetic system
  • Cholinergic agonists
  • Parasympathetic system
  • Drugs affecting pupil size
  • Micturition
  • Drug side effects
  • Acetaminophen
  • Drug overdose/poisoning
  • Antidotes
  • Pharmacologic suffixes
  • Teratogenic drugs

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Psychiatry course review topics in UMock Content Review

 
  • Psychology
  • Childhood disorders
  • Mood disorders
  • Postpartum mood disorders
  • Dissociative disorders
  • Delirium and dementia
  • Psychotic disorders
  • Malingering disorders
  • Anxiety disorders
  • Personality disorders
  • Somatoform disorders
  • Sleep disorders
  • Gender and sexual disorders
  • Eating disorders
  • Psychiatric emergencies
  • Substance use disorders

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Public health course review topics in UMock Content Review

 
  • Epidemiology
  • Biostatistics
  • Ethics
  • Communication skills
  • Healthcare delivery
  • Quality and safety

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The Pulmonary System course review topics in UMock Content Review

 
  • Introduction to the pulmonary system
  • Pulmonary anatomy
  • Pulmonary physiology
  • Respiratory pathophysiology
  • Pulmonary pharmacology

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Renal course review topics in UMock Content Review

 
  • Kidney embryology
  • Kidney macroscopic anatomy
  • Lower urinary system
  • Fluids
  • Electrolytes
  • Kidney microscopic anatomy
  • Kidney physiology
  • Cystic disorders
  • Nephrotic disorders
  • Nephritic disorders
  • Renal failure
  • Urinary casts and stones
  • Urinary tract infections
  • Urinary system tumors

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Reproduction course review topics in UMock Content Review

 
  • Embryology-reproductive system
  • Embryology-male reproduction
  • Embryology-male reproductive system
  • Anatomy-male reproductive system
  • Pathology-male reproductive organs
  • Anatomy-reproductive system
  • Physiology-hypothalamic-pituitary axis
  • Physiology-menstrual cycle
  • Pathology-breast
  • Pathology-vulva
  • Pathology-vagina
  • Pathology-cervix
  • Physiology-embryonic development
  • Physiology-placentation
  • Physiology-placental hormones
  • Physiology-placental steroids
  • Pathology- female reproductive organs
  • Pathology-sex development
  • Pathology-puberty
  • Pathology-postpartum complications
  • Pathology-uterus
  • Pathology-ovaries
  • Pathology-ovarian tumors
  • Pathology-ovaries
  • Physiology-maternal adaptations
  • Physiology-lactation
  • Physiology-pregnancy and infection
  • Physiology -sexual development
  • Physiology–pubertal growth
  • Physiology–sexual development
  • Pathology-gamete interaction
  • Pathology-implantation
  • Pathology-placenta
  • Pathology-fetal blood vessels
  • Pathology-fetal blood vessels
  • Physiology-fertilization
  • Pathology-maternal serum screening
  • Pathology-pregnancy hypertension
  • Pathology-fetal growth
  • Pathology-teratogens
  • Pathology-sex chromosomes
  • Pathology-fallopian tubes
  • Pharmacology-hormone modulators
  • Pharmacology-contraception
  • Physiology-germ cells
  • Physiology-gametogenesis
  • Physiology-gamete interaction
  • Physiology-implantation

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USMLE Step 1 Exam

Help me increase my score in:

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img Pharmacology
img Biochemistry
img Microbiology
img Immunology
img Hematology & Oncology
img Cardiovascular System
img Respiratory System
img Gastrointestinal Tract
img Renal
img Male Reproductive System
img Female Reproductive System
img Endocrine System
img Dermatology
img Nervous System
img Rheumatology and Musculoskeletal
img Behavioral Science
img Embryology
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Pathology 45% - 52%

 

Pathology makes up the majority of content covered on the exam, representing 44-52% of questions. The UMock USMLE® Step 1 prep course presents concise, high-yield content covering pathophysiologic, morphology, and pathogenesis, focused on the core knowledge of disease mechanisms and clinical aspects you need to know for the exam.

The UMock USMLE® Step 1 prep course features high quality pathologic images, gross and microscopic views, as well as radiologic imaging illustrating key concepts, disorders, and abnormal processes to help you gain a complete understanding of subject material.

The course gives the basic concepts in general and systemic pathology for normal and abnormal body-system processes, including:

  • Apoptosis
  • Shock
  • Psammoma Bodies
  • Necrosis
  • Amyloidosis
  • Gastrointestinal
  • Dermatology
  • Infarcts
  • Neurology
  • Male Reproductive
  • Cell Injury
  • Hematology
  • Immunopathology
  • Endocrine
  • Genetics
  • Pulmonary
  • Nutrition
  • Neoplasia
  • Vascular
  • Cardiology
  • Inflammation & Repair
  • Hepatobiliary & Pancreatic
  • Female Reproductive & Pregnancy
  • Renal & Electrolytes Hemodynamics
  • Environmental Pathology
  • Rheumatology & Musculoskeletal
  • Erythrocyte Sedimentation Rate
  • Leukocyte Extravasation
  • Transudate vs. Exudate
  • Free Radical Injury
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Physiology 25% - 35%

 

Physiology is the second largest subject covered on Step 1, representing approximately 25-35% of questions. The UMock USMLE® Step 1 prep course provides a to-the-point, yet highly detailed review of concepts to help you understand the relationship between physiology and medicine, and explains in detail how systems work together to maintain homeostasis.

The course contains high quality illustrations, flow charts, diagrams, and tables highlighting core knowledge you need to build long-term memory and apply knowledge to body-system processes for every topic covered on the exam.

  • Nerve & Muscle
  • Heart
  • Space
  • Circulation
  • Regulation
  • Endocrinology
  • Respiration
  • Blood Cells
  • Immunity
  • Aviation
  • Neurophysiology
  • Diving Physiology
  • Blood Coagulation
  • Gastrointestinal Physiology
  • Metabolism & Temperature
  • Cell & General Physiology
  • Membrane Physiology
  • Male Reproduction
  • Female Reproduction
  • Body Fluids and Kidneys
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Pharmacology Content Review 15% - 22%

 

Pharmacology accounts for roughly 15-22% of questions covered on the exam. The UMock USMLE® Step 1 prep course presents a comprehensive overview in a concise chapter-by-chapter format to help you gain an understanding of the principles in pharmacology and their classification, pharmacodynamic and pharmacokinetic processes, the mechanism of the action of drugs, usage, and their adverse effects.

The course features high quality images, illustrations, and informative diagrams to help you learn basic core knowledge in pharmacology, and how it applies to normal and abnormal body-system processes.

  • Pharmacodynamics
  • Pharmacokinetics
  • Drug Misuse, Pain & Anesthesia
  • Inflammation & Immunosuppression
  • Infectious Diseases
  • Cancer
  • Allergic Diseases
  • Peripheral & Central Nervous System Pharmacology
  • Respiratory Pharmacology
  • Cardiovascular Pharmacology
  • Kidney & Urinary Pharmacology
  • Gastrointestinal Pharmacology
  • Endocrine & Reproductive System Pharmacology
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Biochemistry Content Review 14% - 22%

 

Biochemistry makes up about 14-22% of questions you’ll see on the exam. The UMock USMLE® Step 1 prep course provides an in-depth and condensed review that helps you understand how to connect biochemical concepts and easily memorize high-yield metabolic pathways and associated enzymes.

The course includes diagrams and conceptual images with specific enzyme names and pathways to help you to increase recall and gain a thorough understanding of how to apply biochemical concepts on the exam.

  • Fuel Metabolism & Nutrition
  • Organic Chemistry
  • Acid-Base Chemistry
  • Amino Acids
  • Protein Structure & Function
  • Enzyme Kinetics
  • Molecular Endocrinology
  • Gene Expression
  • Synthesis of Proteins
  • Regulation of Gene Expression
  • Cell Biology
  • Signal Transduction
  • Molecular Biology of Cancer
  • Tissue Metabolism
  • Generation of ATP from Metabolic Fuels
  • Oxygen Toxicity
  • Carbohydrate Metabolism
  • Lipid and Ethanol Metabolism
  • Nitrogen Metabolism: Amino Acids, Purines, Pyrimidines, and Products Derived from Amino Acids
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Microbiology Content Review 10% - 15%

 

Microbiology represents approximately 10-15% of exam questions, requiring memorization and applying concepts. The course includes high quality micro classification charts and slides for Gram (+) and Gram (-) rods to help you visualize and understand the application of microbiology in basic medical science.

The UMock USMLE® Step 1 prep course presents a concise review of high-yield content in an easy-to-learn review of medical microbiology covering basic bacteriology, clinical bacteriology, viruses, mycology, and parasitology. UMock provides the concepts for microbiology to help you understand how to apply concepts to clinical scenarios for Step 1.

  • Mycology
  • Bacteria
  • Immunology
  • Viruses
  • Parasitology
  • Fungal Diseases
  • Parasitic Diseases
  • Bacterial Diseases
  • Important Bacterial Genera
  • General Properties of Microorganisms
  • Distinguishing Causative Infection Agents
  • System-based and Situational Viral Infections
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Immunology Content Review 6% - 11%

 

Immunology accounts for roughly 6-11% of exam questions. The UMock USMLE® Step 1 prep course helps you gain an understanding of how systems interrelate in the context of the overall immune system. The course presents high-yield topics in a clear and simple way to help you memorize and understand how to apply heavily tested concepts to clinical scenarios.

  • Cytokines
  • Amyloidosis
  • Autoimmunity
  • Complement System
  • Human Leukocyte Antigen System
  • Innate Versus Acquired Immunity
  • Cells of the Immune System
  • Transplantation Immunology
  • Immunodeficiency Diseases
  • Mechanisms of Immune Injury
  • Connective Tissue (Collagen) Diseases
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Hematology and Oncology Content Review 7% - 11%

 

In Hematology, the UMock USMLE Step 1 prep course review gives you a comprehensive yet concise review of high-yield topics to promote better memorization and understanding of concepts to apply in clinical scenarios, including hematologic malignancies, blood disorders, hematopoietic cell transplantation, transfusion medicine, hemostasis, thrombosis, and standard treatment regimens.

In Oncology, the course presents a complete review of concise high-yield concepts to help you deeply understand, memorize, and apply concepts to scenarios covering solid tumor malignancies, anticancer therapies, bone marrow transplantation, neoplasms, clinical research methodology, palliative care, survivorship, and treatment recommendations.

  • Oncology
    • General Concepts
    • Acute Posthemorrhagic Anemia
    • Iron Deficiency Anemia
    • Megaloblastic Anemias
    • Anemia of Chronic Disease
    • Aplastic Anemia
    • Myelophthisic Anemia
    • Hemolytic Anemias
    • Leukemia
    • Myeloproliferative Diseases
    • Non-Neoplastic Lymphoid Proliferations
    • Plasma Cell Disorders
    • Lymphoid Neoplasms
  • Hematology
    • General Considerations
    • Classification & Nomenclature of Tumors
    • Properties of Neoplasms
    • Carcinogenesis & Etiology
    • Other Neoplastic Disorders with Known DNA Defects
    • Grading & Staging
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Cardiovascular System Content Review 5% - 9%

 

Cardiology accounts for approximately 5-9% of test items. The UMock USMLE® Step 1 prep course provides a concise high-yield review of pathologies that affect the cardiovascular system, diagnostic methods, pharmacotherapies, and management thereof to help you deeply understand, recall, and apply concepts to various clinical scenarios.

The course material is integrated with EKG tracings and illustrated with high quality microscopic views, as well as radiological and gross images highlighting normal and abnormal processes of diseases to give you a complete understanding of the clinical application of medicine in cardiology.

  • Ischemic Heart Disease (IHD)
  • Rheumatic Fever
  • Other Forms of Endocarditis
  • Valvular Heart Disease
  • Congenital Heart Disease
  • Disease of the Myocardium
  • Diseases of the Pericardium
  • Tumors of the Heart
  • Congestive Heart Failure
  • Hypertrophy of the Heart
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Respiratory System Content Review 9% - 13%

 

The UMock USMLE® Step 1 prep course provides a condensed, high-yield review of concepts to help you fully understand normal and abnormal pulmonary processes, and how to apply knowledge to clinical scenarios relating to pathologies that affect the lungs, pulmonary function tests, ventilation/perfusion mismatch, and cell types and their function based on their location in the respiratory tract.

The course includes volume calculations as well as high quality graphs and diagrams to help you learn exactly what is tested from each topic, and how to apply it to respiratory medicine.

  • Cancers of the Lungs
  • Pulmonary Vascular Disease
  • Restrictive Pulmonary Disease
  • Miscellaneous Disorders of the Lungs
  • Tumors of the Upper Respiratory Tract
  • Chronic Obstructive Pulmonary Disease
  • Disorders of the Upper Respiratory Tract
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Gastrointestinal Tract Content Review 5% - 9%

 

The gastrointestinal system represents roughly 5-9% of test items. The UMock USMLE® Step 1 prep course gives you a comprehensive and concise review of high-yield material to help you memorize, understand, and apply information to clinical scenarios pertaining to concepts of digestion and how one factor is affected by another, malabsorption syndromes, as well as the histopathology type of each location, and where the pharmacotherapies take action.

The course features high quality diagnostic images and microscopic views covering normal and abnormal processes of diseases to help you accurately interpret and apply concepts in gastroenterology for the exam.

  • Diseases of the Colon
  • Diseases of the Appendix
  • Diseases of the Stomach
  • Diseases of the Esophagus
  • Diseases of the Mouth and Jaw
  • Diseases of the Small Intestine
  • Diseases of the Salivary Glandsw
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Renal and Urinary System Content Review 9% - 13%

 

The renal and urinary system make up questions heavily weighted on physiology-focused concepts. The UMock USMLE® Step 1 prep course provides a high-yield review of essential concepts in a clear and concise format to help you understand and apply the connection between renal tubule physiology and the diuretics that work on the tubule, as well as applying concepts in nephritic and nephrotic syndromes to clinical scenarios.

The course includes high quality radiological images and microscopic views highlighting normal and abnormal processes specific to renal and urinary diseases to give you a distinguished understanding of the application of concepts in clinical scenarios.

  • Hemodynamic
  • Urolithiasis
  • Hemodynamic
  • Renal Failure
  • Nephrocalcinosis
  • Glomerular Diseases
  • Cystic Diseases of Kidney
  • Hemodynamic Dysfunction
  • Urinary Tract Obstruction
  • Diffuse Cortical Necrosis
  • Nonrenal Causes of Azotemia
  • Infection of the Urinary Tract and Kidney
  • Congenital Anomalies of the Urinary Tract
  • Tumors of the Kidney, Urinary Tract, & Bladder
  • Tubular and Interstitial Disorders of the Kidney
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Male Reproductive System Content Review 9% - 13%

 

In the reproductive system, the UMock USMLE® Step 1 prep course covers the male and female reproductive system as well as pregnancy, childbirth, and the puerperium. The course provides high-yield topics concentrated on clear and concise explanations to help you understand and apply concepts to clinical scenarios associated with the hormonal pathways of the male and female reproductive systems.

The course integrates concepts with high quality microscopic views and diagnostic images to help you improve recall of normal and abnormal processes in disease and apply it to clinical scenarios like you’ll see on the exam.

  • Diseases of the Penis
  • Diseases of the Testes
  • Diseases of the Prostate
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Female Reproductive System Content Review 9% - 13%

 

In the reproductive system, the UMock USMLE® Step 1 prep course covers the male and female reproductive system as well as pregnancy, childbirth, and the puerperium. The course provides high-yield topics concentrated on clear and concise explanations to help you understand and apply concepts to clinical scenarios associated with the hormonal pathways of the male and female reproductive systems.

The course integrates concepts with high quality microscopic views and diagnostic images to help you improve recall of normal and abnormal processes in disease and apply it to clinical scenarios like you’ll see on the exam.

  • Ovaries
  • Breast
  • Vulva & Vagina
  • Uterine Cervix
  • Uterine Corpus
  • Fallopian Tubes
  • Disorders of Pregnancy
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Endocrine System Content Review 9% - 13%

 

The UMock USMLE® Step 1 prep course combines concise high yield topics with detailed diagrams covering normal and abnormal processes of endocrine-specific pathologies and physiologies. The course helps you gain a clear understanding of how to apply concepts to clinical scenarios for keeping hormone levels in balance, diagnostic testing, treatment, and management.

The course includes descriptive illustrations, microscopic views, images, and graphs highlighting heavily test exam content to help you gain a full understanding of applying concepts for normal and abnormal processes of the endocrine system.

  • Endocrine Pancreas
  • Endocrine of Pituitary
  • Endocrine of Thyroid Gland
  • Endocrine of Adrenal Glands
  • Endocrine of Parathyroid Glands
  • Multiple Endocrine neoplasia (MEN) Syndrome
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Dermatology Content Review 6% - 10%

 

In Dermatology, the UMock USMLE® Step 1 prep course gives you concise, high yield topics to help you understand how to apply basic concepts to clinical scenarios in comparing similar pathologies based on the morphology and distribution of conditions.

Every topic is covered for both normal and abnormal body-system processes with high quality microscopic views and gross images to help you visually understand the application of medicine specific to diseases in skin and subcutaneous tissue.

  • Pruritus
  • Urticaria
  • Common Rashes
  • Infestations
  • Bites & Stings
  • Hair Disorders
  • Common Neoplasms
  • Acneiform Eruptions
  • Common Skin Infections
  • Cuts, Scrapes, & Burns
  • Foot and Leg Ulcers
  • Nail Disorders
  • Disorders of Mucous Membranes
  • Autoimmune Blistering Diseases
  • Therapeutic Principles in Dermatology
  • Dermatologic Urgencies and Emergencies
  • Cutaneous Manifestations of Internal Disease
  • Dermatologic Problems of Special Populations
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Nervous System Content Review 4% to 7%

 

Exam items covering the nervous system represent about 4-7% of test questions. The UMock Step 1 Prep Course clearly explains gross anatomy and neuroanatomy and normal and abnormal processes from this area, including

  • Embryonic development
  • Fetal maturation
  • Perinatal changes
  • Neural tube derivatives
  • Cerebral ventricles
  • Neural crest derivatives
  • Organ structure & function
  • Cell & tissue structure & function
  • Repair
  • Regeneration
  • Changes associated with life stages
  • Infectious
  • Immunologic
  • Inflammatory disorders
  • Neoplasms
  • Cerebrovascular disease
  • Disorders related to spinal cord
  • Spine
  • Spinal nerve roots
  • Cranial & peripheral nerve disorders
  • Neurologic pain syndromes
  • Degenerative disorders
  • Global cerebral dysfunction
  • Neuromuscular
  • Metabolic disorders
  • Paroxysmal disorders
  • Sleep disorders
  • Traumatic & mechanical disorders
  • Increased intracranial pressure
  • Congenital disorders
  • Disorders of the eye & eyelid
  • Disorders of the ear
  • Movement disorders
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Rheumatology and Musculoskeletal Content Review 6% - 10%

 

The UMock USMLE® Step 1 prep course provides the most valuable exam information with a complete and concise review of high-yield topics to help you quickly understand and apply knowledge to clinical scenarios covering the diagnosis of joint pathologies, and anatomical paths of distal branches and the muscles that they innervate.

The course features detailed tables and high quality radiologic and gross images to help you conceptualize the application of medicine for normal and abnormal body system processes and pathologies in rheumatology and the musculoskeletal system.

  • Diseases of Skeletal Muscle
  • Diseases of Bone
  • Diseases of Joints
  • Soft-Tissue Tumors
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Behavioral Science Content Review 8% to 13%

 

Behavioral science accounts for roughly 8-13% of exam questions. The UMock USMLE® Step 1 prep course helps you clarify difficult concepts in the mind-body relationship, and understand how to apply DSM-IV and DSM-5 diagnostic criteria in the manifestations of psychological disorders to various clinical scenarios with a high-yield, concise review of concepts covering every topic for normal and abnormal processes.

The course includes descriptive diagrams, tables, and images to provide a concentrated review of material to help you fully understand the application of behavioral science to clinical medicine.

  • Sexuality
  • Learning Theory
  • Beginning of Life
  • Anxiety Disorders
  • Aggression & Abuse
  • Psychosomatic Medicine
  • Somatic Symptom Disorders
  • Obsessive-Compulsive Disorders
  • Trauma & Stressor-Related Disorders
  • Substance-related Disorders
  • Sleep & Sleep-wake Disorders
  • Psychological Therapies
  • Family, Culture, & Illness
  • Psychiatrics Disorders in Children
  • Aging, Death, & Bereavement
  • School Age, Adolescence, & Adulthood
  • Psychoanalytic Theory & Defense Mechanisms
  • Depressive Disorders & Bipolar Disorders
  • Schizophrenia Spectrum & other Psychotic Disorders
  • Clinical Assessment of Patients with Behavioral Symptoms
  • Biological Assessment of Patients with Psychiatric Symptoms
  • Neurocognitive, Personality, Dissociative & Eating Disorders
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Embryology Content Review 11% - 15%

 

In Embryology, the UMock USMLE® Step 1 prep course presents high-yield content in a concise format that helps you understand and quickly recall concepts in human development and congenital malformations, and apply the connection between embryological knowledge and clinical medicine. The course further clarifies key facts and concepts to help you maximize comprehension and visual understanding in applying concepts with high quality diagnostic, radiographic, and clinical images.

  • Skeletal System
  • Muscular System
  • Upper Limb
  • Lower Limb
  • Body Cavities
  • Pregnancy
  • Teratology
  • Head & Neck
  • Prefertilization Events
  • Human Development - Week 1
  • Human Development - Week 2
  • Embryonic Period
  • Cardiovascular System
  • Placenta & Amniotic Fluid
  • Embryology of the Ear
  • Embryology of the Eye
  • Embryology of the Nervous
  • Embryology of the Digestive
  • Embryology of the Respiratory
  • Urinary System
  • Female Reproductive System
  • Male Reproductive System
  • Integumentary System
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Women’s Health and Pregnancy Content Review 3% to 5%

 

The musculoskeletal system accounts for roughly 3-5% of the exam. Learn everything covered on this section of the exam for normal and abnormal process with the UMock Step 1 Prep Course:

  • Tendon
  • Repair
  • Joints
  • Usage
  • Muscles
  • Cartilage
  • Arthritis
  • Infectious
  • Regeneration
  • Blood supply
  • Gross anatomy
  • Neoplasms
  • Embryonic development
  • Organ structure & function
  • Changes associated with life stages
  • Cell & tissue structure & function
  • Ligaments & fascia
  • Traumatic & mechanical disorders
  • Mechanism of the action of drugs
  • Fetal maturation & perinatal changes
  • Inflammatory & immunologic disorders
  • Adverse effects on the musculoskeletal system
  • Degenerative & metabolic disorders of bone
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Histology Content Review 8% to 13%

 

Histology makes up about 8-13% of questions on the exam. The UMock USMLE® Step 1 prep course offers a high-yield review condensed concepts format to help you better understand the relationship between cell structure and function to biological tissues, and effectively apply concepts to clinical scenarios on the exam. The course includes high quality micrographs, illustrations, and tables to further enhance your ability to quickly recall concepts and how they apply in clinical practice.

  • Cell Histology
  • Extracellular Matrix
  • Epithelia & Glands
  • Connective Tissue
  • Blood & Hemopoiesis
  • Histology Cartilage & Bone
  • Histology Muscle
  • Nervous Tissue
  • Circulatory System
  • Histology of Lymphoid
  • Histology of Endocrine
  • Histology of Skin
  • Histology of Respiratory
  • Histology of Digestive
  • Urinary Glands
  • Female Reproductive
  • Male Reproductive
  • Special Senses
  • Cavity and Alimentary Tract
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Anatomy Content Review 11% to 15%

 

In Anatomy, the UMock USMLE® Step 1 prep course presents the most important high-yield facts you need to memorize for the exam, and helps you understand and apply clinical correlations of the structure and organization of the body to clinical scenarios such as fractures, trauma, and injuries. The course is illustrated with high quality descriptive images of anatomic relationships to further enhance your ability to apply knowledge to concepts.

  • Perineum
  • Vertebral Column
  • Spinal Cord & Spinal Nerves
  • Autonomic Nervous System
  • Lymphatic System
  • Chest Wall
  • Anatomy of the Heart
  • Abdominal Wall
  • Kidney, Ureter, Bladder, & Urethra
  • Suprarenal Glands
  • Abdominal Vasculature
  • Abdominal Viscera
  • Anatomy of the Pelvis
  • Spleen
  • Female Reproductive
  • Male Reproductive
  • Anatomy of the Upper Limb
  • Anatomy of the Lower Limb
  • Anatomy of the Head
  • Anatomy of the Neck
  • Anatomy of the Eye
  • Anatomy of the Ear
  • Pleura, Tracheobronchial Tree, & Lungs
  • Sigmoid Colon, Rectum, & Anal Canal
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Neuroanatomy Content Review 9% to 13%

 

In Neuroanatomy, the UMock USMLE® Step 1 prep course provides high-yield concepts in a clear and concise presentation to help you thoroughly understand and apply concepts in clinical scenarios covering different pathways and tracts, patterns, distribution territories, and the results of lesions.

In Neurology, the UMock USMLE® Step 1 prep course offers a clear and concise approach to helping you understand and apply concepts to clinical scenarios with high yield concepts covering the relationship between nerves and neurotransmission, and neurologic disease

The course features high quality illustrations, detailed tables, and radiologic images for both normal and abnormal processes to help you better understand how to apply concepts for diagnosis, treatment and management of neurologic diseases.

  • Cerebellum
  • Neurohistology
  • Cranial nerves
  • Auditory System
  • Vestibular System
  • Cerebral Cortex
  • Visual System
  • Gross Anatomy of the Brain
  • Tracts of the Trigeminal system
  • Meninges & Cerebrospinal Fluid
  • Development of the Nervous System
  • Olfactory, Gustatory, & Limbic
  • Autonomous Nervous System
  • Neurotransmitters & Pathways
  • Diencephalon: Thalamus & Hypothalamus
  • Blood supply of the Central Nervous System
  • Tracts & Lesions of the Spinal Cord & Brainstem
  • Tracts & Lesions of the Spinal Cord & Brainstem
  • Basal Nuclei & the Extrapyramidal Motor System
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Legal and Ethics Content Review 6% to 10%

 

The UMock USMLE® Step 1 prep course gives you a clearly explained review of high-yield topics to help you understand how to apply, and make a decision in clinical scenarios involving calculated risks, promoting the patients’ best interest, and respecting the patient’s decisions about their own health. Topics from the course include:

  • Minors
  • Abortion
  • Refusing Care
  • Confidentiality
  • Informed Consent
  • Abuse & Neglect
  • Reportable Diseases
  • Ethical Principles
  • Healthcare Legislation
  • Capacity & Competency
  • Physician Assisted Suicide
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Biostatistics and Epidemiology Content Review 4% to 6%

 

Biostatistics and Epidemiology covers roughly 4-6% of exam questions. The UMock USMLE® Step 1 prep course clarifies difficult concepts with a concise review of high-yield concepts. The course eliminates excessive detail to help you memorize and understand how to efficiently identify and extract the most important information, and apply your knowledge to concepts and formulas. The course includes high quality graphs and tables that clearly illustrate the most important and heavily tested concepts you need to know how to apply for the exam, including:

  • Research Methods
  • Hypothesis Testing
  • Descriptive Statistics
  • Differential Statistics
  • Assessing the Evidence
  • Correlational & Predictive Techniques
  • Statistics in Medical Decision Making
  • Epidemiology & Population Health
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Biostatistics and Epidemiology Content Review 4% to 6%

 

Biostatistics and Epidemiology covers roughly 4-6% of exam questions. The UMock USMLE® Step 1 prep course clarifies difficult concepts with a concise review of high-yield concepts. The course eliminates excessive detail to help you memorize and understand how to efficiently identify and extract the most important information, and apply your knowledge to concepts and formulas. The course includes high quality graphs and tables that clearly illustrate the most important and heavily tested concepts you need to know how to apply for the exam, including:

  • Research Methods
  • Hypothesis Testing
  • Descriptive Statistics
  • Differential Statistics
  • Assessing the Evidence
  • Correlational & Predictive Techniques
  • Statistics in Medical Decision Making
  • Epidemiology & Population Health
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